Prednitab 5 mg, 30 tabs
Prednitab 5 Tablets
Each tablet contains Prednisolone 5 mg.
Prednisolone is a synthetic glucocorticoid with the general properties of the corticosteroids.
Prednisolone exceeds hydrocortisone in glucocorticoid and anti-inflammatory activity, being about
three times more potent on a weight basis than the parent hormone, but is considerably less active
than hydrocortisone in mineralocorticoid activity.
Prednisolone, like hydrocortisone, is a potent therapeutic agent influencing the biochemical behavior
of most tissues of the body. The mechanism of action of corticosteroids is thought to be by control of
protein synthesis. Corticosteroids react with receptor proteins in the cytoplasm of sensitive cells in
many tissues to form a steroid-receptor complex.
Corticosteroids are palliative symptomatic treatment of virtue of their anti-inflammatory effects; they
are never curative.
Prednisolone is rapidly and well absorbed from the gastrointestinal tract following oral
administration. Prednilet produces a 20% higher peak plasma level of prednisolone that occurs
approximately 15 minutes earlier than the peak seen with tablet formulations. Prednisolone is 90-95%
protein-bound, less so at higher doses. The apparent volume of distribution for unbound
prednisolone is 1.5 ± 0.2 L/kg. Prednisolone is eliminated from the plasma with a half-life of 2 to 4
hours. It is metabolised mainly in the liver and excreted in the urine as sulphate and glucuronide
Dosage and Administration
The maximal activity of the adrenal cortex is between 2 a.m. and 8 a.m.; it is minimal between 4 pm.
and midnight. Exogenous corticosteroids suppress adrenocortical activity the least when given at the
time of maximal activity (a.m.). Therefore, glucocorticoids should be administered before 9 a.m.
When large doses are given, antacids may be administered between meals to help prevent peptic